Trimetazidine and the metabolic profile of ischemia
نویسنده
چکیده
Trimetazidine, a metabolic agent, acts at the cellular level to improve myocardial metabolism at the time of ischemia. A recent Cochrane Collaboration review of its use in stable angina has confirmed its effectiveness in reducing anginal attacks and nitrate consumption, at the same time as improving exercise performance with minimal adverse events. Additional reports identifying improved left ventricular function in cardiac failure suggest a potential prognostic role. Heart Metab. 2006;32:26–27.
منابع مشابه
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia
OBJECTIVE Myocardial ischemia affects mitochondrial functions, leading to ionic imbalance and susceptibility to ventricular fibrillation. Trimetazidine, a metabolic agent, is clinically used in anti-anginal therapy. METHODS In this study, the rats were orally treated by gavage with trimetazidine 10 mg/kg/d for 7 days, and the effects of trimetazidine on mitochondrial respiratory function, bio...
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تاریخ انتشار 2006